Investigating how gut bacteria affect gut and brain function in autism.
Official title: Does microbiome composition moderate GI and CNS function in a VPA-induced mouse model of autism?
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-10753699 · Data updated 2026-11-12
This study is looking at how the bacteria in the gut might affect both tummy troubles and behaviors in mice with autism, hoping to find new ways to help people with similar challenges.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 12, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $430,375 |
| NIH project number | 1R21HD112101-01A1 |
| Project ID | NIH-10753699 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autism who experience gastrointestinal symptoms.
✕Less likely to help
Patients without autism or those who do not have gastrointestinal issues may not benefit from this research.
What this research studies
This research explores the relationship between gut microbiome composition and gastrointestinal (GI) and central nervous system (CNS) function in a mouse model of autism. By examining how different gut bacteria influence GI symptoms and behaviors associated with autism, the study aims to uncover biological mechanisms that may lead to better interventions. The researchers will create groups of mice with varying gut microbiomes to assess their impact on GI function and behavior, providing insights that could translate to human health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for gastrointestinal issues commonly experienced by autistic individuals.
How similar studies have gone: Previous studies have shown promising results in understanding the gut-brain connection in autism, indicating potential for success in this area.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Knickmeyer, Rebecca — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Knickmeyer, Rebecca
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.