Investigating how gut bacteria affect food allergies in children
Targeting microbial dysbiosis in Food Allergy to restore tolerance
This study is looking at how the bacteria in kids' tummies might help their bodies get used to certain foods and avoid allergies, especially as they start eating solid foods after breastfeeding.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11012870 on NIH RePORTER |
What this research studies
This research explores the connection between gut bacteria and food allergies, particularly in young children. It focuses on how certain bacteria can help the immune system develop tolerance to food, potentially preventing allergic reactions. The study examines the changes in gut bacteria during the transition from breast milk to solid foods and how these changes influence immune responses. By understanding these mechanisms, the research aims to identify new strategies for treating and preventing food allergies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who are at risk of developing food allergies or have already been diagnosed with them.
Not a fit: Patients who are adults or those without a history of food allergies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help children develop tolerance to food allergens, reducing the prevalence of food allergies.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut bacteria in immune responses, suggesting that this approach could be effective.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chatila, Talal Amine — Boston Children's Hospital
- Study coordinator: Chatila, Talal Amine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.