Investigating how gut bacteria affect Alzheimer's disease through brain cells
The gut microbiome in Alzheimer's disease: exploring the role of astrocytes
This study is looking at how the bacteria in your gut might affect brain health and Alzheimer's disease, especially by checking how certain brain cells react to changes in gut bacteria, and it could help find new ways to treat Alzheimer's.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10906962 on NIH RePORTER |
What this research studies
This research explores the connection between the gut microbiome and Alzheimer's disease by focusing on the role of astrocytes, a type of brain cell. The study aims to understand how changes in gut bacteria, potentially influenced by antibiotics, can impact neuroinflammation and the formation of amyloid plaques in the brain. By examining the interactions between gut health and brain function, the research seeks to uncover new therapeutic targets for Alzheimer's disease. Patients may be involved in assessments that analyze their gut microbiome and its effects on cognitive health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that modify the gut microbiome to slow or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of the gut microbiome in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Chandra, Sidhanth — Northwestern University at Chicago
- Study coordinator: Chandra, Sidhanth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.