Investigating how gut bacteria affect aging immune cells
Microbiome and immunosenescence of T cells repertoire
This study is looking at how the bacteria in our gut can help boost the immune system in older people, especially those who are frail, by creating a special mix of gut bacteria that might improve their health and immune responses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10836021 on NIH RePORTER |
What this research studies
This research explores the role of gut microbiota in influencing the immune system, particularly focusing on CD4 T cells in older individuals. The study aims to develop a standardized collection of gut bacteria that can help restore balance in the intestines of frail elderly patients. By administering this tailored microbiome to older mice and humans, the researchers hope to understand how specific bacteria can rejuvenate aging immune responses and improve overall health. The approach includes examining how these bacteria interact with immune cells and their potential to convert certain T cells into regulatory cells that help maintain immune balance.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those who are frail or experiencing age-related immune decline.
Not a fit: Patients who are younger or have a robust immune system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new microbiome-based therapies that enhance immune function in older adults, potentially improving their health and quality of life.
How similar studies have performed: Previous research has shown promise in using microbiome therapies to improve health outcomes, suggesting that this approach could be effective.
Where this research is happening
Atlanta, United States
- Georgia State University — Atlanta, United States (Active)
Researchers
- Principal investigator: Ignatowicz, Leszek — Georgia State University
- Study coordinator: Ignatowicz, Leszek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.