Investigating how growth hormone affects appetite and metabolism in humans
Central Mediation of Growth Hormone Effects in Humans
This study is looking at how growth hormone affects hunger and metabolism in people with acromegaly, and it will also test if a medication called liraglutide can help manage appetite by lowering a hunger-related substance in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11055403 on NIH RePORTER |
What this research studies
This research explores the role of growth hormone (GH) in regulating appetite and metabolism, particularly focusing on a neuropeptide called AgRP that is involved in hunger signaling. By studying patients with acromegaly, a condition characterized by excess GH, the researchers aim to understand how GH influences AgRP levels and appetite. The study will also examine the effects of a medication called liraglutide, which may lower AgRP levels and help manage appetite. Patients will be monitored for changes in hormone levels and metabolic responses throughout the study.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with acromegaly or those experiencing related metabolic issues.
Not a fit: Patients who do not have acromegaly or related hormonal disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for managing appetite and body weight in individuals with hormonal imbalances.
How similar studies have performed: Previous research has shown promising results in animal models regarding the effects of growth hormone on appetite regulation, but this study aims to confirm these findings in humans.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Freda, Pamela U — Columbia University Health Sciences
- Study coordinator: Freda, Pamela U
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.