Investigating how Group B Streptococcus interacts in complex environments like pregnancy and diabetic wounds
Official title: The Role of the Group B Streptococcus Type VII Secretion System in Polymicrobial Environments
Funded at University of Colorado Denver · NIH-11067530 · Data updated 2026-11-12
This study is looking at how a germ called Group B Streptococcus (GBS) behaves in pregnant women and people with diabetes, to help us understand how it survives and interacts with other germs, which could lead to better treatments for infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $37,529 |
| NIH project number | 1F31AI183560-01A1 |
| Project ID | NIH-11067530 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant women and individuals with diabetes who are at risk for infections related to Group B Streptococcus.
✕Less likely to help
Patients who do not have a history of Group B Streptococcus infections or are not part of the targeted populations may not receive benefit from this research.
What this research studies
This research focuses on understanding the behavior of Group B Streptococcus (GBS), a bacterium that can cause serious health issues in pregnant women and individuals with diabetes. The study examines how GBS uses its Type VII Secretion System to compete with other bacteria in environments such as the vaginal tract and diabetic wounds. By exploring the mechanisms of GBS colonization and persistence, the research aims to uncover new insights into bacterial interactions and their implications for health. Patients may benefit from a better understanding of GBS and its role in infections, potentially leading to improved treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for infections caused by Group B Streptococcus, particularly in vulnerable populations.
How similar studies have gone: Previous research has shown that understanding bacterial competition and virulence factors can lead to significant advancements in treating infections, suggesting that this approach has potential for success.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Job, Alyx M — University of Colorado Denver
- Study coordinator: Job, Alyx M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.