Investigating how Group B Streptococcus affects diabetic wound infections
Official title: Host-pathogen interactions during GBS diabetic wound infections
Funded at University of Colorado Denver · NIH-11094680 · Data updated 2026-11-12
This study is looking at how a common germ called Group B Streptococcus affects wounds in people with diabetes, hoping to find ways to help these wounds heal better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $38,222 |
| NIH project number | 5F31AI178881-02 |
| Project ID | NIH-11094680 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have diabetes and are experiencing chronic wounds.
✕Less likely to help
Patients without diabetes or those who do not have chronic wounds may not benefit from this research.
What this research studies
This research focuses on understanding the interactions between Group B Streptococcus (GBS) and diabetic wounds. It aims to explore how GBS, a common bacterium, contributes to infections in individuals with diabetes, particularly those with chronic wounds. The study utilizes advanced techniques like dual RNA-sequencing to analyze infected tissues and identify key metal transport systems that may influence the infection process. By examining these interactions, the research seeks to uncover potential targets for improving wound healing in diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating infections in diabetic patients with chronic wounds.
How similar studies have gone: Previous research has shown success in understanding bacterial infections in diabetic wounds, indicating that this approach has potential for meaningful insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Akbari, Madeline Sohayla — University of Colorado Denver
- Study coordinator: Akbari, Madeline Sohayla
Related research
Other NIH-funded projects on the same topics.
-
Diabetic Foot Ulcer Healing Network at the University of Arizona
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-
Understanding how skin layers coordinate healing after injury
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-
Immunomodulatory therapy to speed up healing after oral cavity injuries in kids
A new approach using a drug called FTY720 aims to improve healing and reduce pain after oral injuries or palate surgery in children.
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How diabetic wounds let Group B Streptococcus cause infections
Researchers are learning how high blood sugar, immune changes, and other bacteria in diabetic wounds help Group B Streptococcus grow and cause worse infections in people with diabetes.
-
Understanding how skin cells exchange harmful chemicals to cause injury and wound repair
A research project aims to uncover how certain chemical agents damage human skin and what happens in the early stages of blistering and inflammation.
-
Intestinal mucosal wound healing in humans
A patient-friendly look at how the lining of the gut repairs itself after injury and why this matters for conditions like inflammatory bowel disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.