Investigating how GPRASP proteins regulate blood stem cells
Official title: GPRASP family as novel regulators in hematopoietic stem cells
Funded at University of Michigan at Ann Arbor · NIH-10906324 · Data updated 2026-11-12
This study is looking at how certain proteins help blood stem cells survive and work better after being transplanted, with the goal of improving outcomes for patients who need these transplants, especially when donor cells are hard to find or have been changed.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $239,040 |
| NIH project number | 5R00DK123395-04 |
| Project ID | NIH-10906324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with hematologic diseases, such as leukemia, who may require hematopoietic stem cell transplantation.
✕Less likely to help
Patients with non-hematologic conditions or those who do not require stem cell transplantation may not benefit from this research.
What this research studies
This research focuses on understanding how specific proteins, known as GPRASPs, influence the behavior of hematopoietic stem cells (HSCs), which are crucial for producing blood cells. The study aims to identify the molecular mechanisms that allow transplanted HSCs to survive and thrive in their new environment, particularly after procedures like stem cell transplants. By examining how these proteins affect HSC function, the research seeks to improve outcomes for patients undergoing hematopoietic stem cell transplantation, especially in challenging cases where donor cells are limited or manipulated. The approach includes analyzing the expression of GPRASPs in HSCs and their impact on cell homing and survival during transplants.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for hematopoietic stem cell transplantation, enhancing patient outcomes in treating blood diseases like leukemia.
How similar studies have gone: Previous research has shown promising results in understanding the regulation of hematopoietic stem cells, suggesting that this approach could lead to significant advancements in the field.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Morales-Hernandez, Antonio — University of Michigan at Ann Arbor
- Study coordinator: Morales-Hernandez, Antonio
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.