Investigating how GPR84 signaling affects skin healing
The role of GPR84 signaling during skin repair
This study is looking at how a specific signaling process in the skin can help improve healing, especially for people with diabetes or older adults, by understanding how fat breakdown affects inflammation and wound recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11039978 on NIH RePORTER |
What this research studies
This research explores the role of GPR84 signaling in the process of skin repair, particularly focusing on how lipid signaling influences inflammation and tissue healing. The study aims to identify the mechanisms by which adipocyte lipolysis affects macrophage activity and overall wound healing. By understanding these processes, the research seeks to uncover new therapeutic targets for improving healing in patients with acute wounds, especially those who are diabetic or elderly. The approach includes both in vitro and in vivo experiments to assess the effects of GPR84 activation on skin inflammation and repair.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with acute wounds, particularly those who are elderly or have diabetes.
Not a fit: Patients with chronic wounds unrelated to inflammation or those without skin repair issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance wound healing and reduce complications in patients with non-healing wounds.
How similar studies have performed: While the specific role of GPR84 in skin repair is not well established, similar lipid signaling pathways have shown promise in other areas of inflammation and wound healing.
Where this research is happening
Washington, United States
- George Washington University — Washington, United States (Active)
Researchers
- Principal investigator: Shook, Brett — George Washington University
- Study coordinator: Shook, Brett
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.