Investigating how GPR75 affects obesity-related heart and metabolic issues
Official title: GPR75 in obesity-driven cardiovascular and metabolic complications
Funded at New York Medical College · NIH-11037960 · Data updated 2026-11-12
This study is looking at how a specific protein called GPR75 affects health problems related to obesity, like heart disease and metabolic syndrome, to find new ways to help people with these conditions feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Medical College NIH-funded |
| Lab location | 1 site (Valhalla, United States) |
| Project start | April 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $510,454 |
| NIH project number | 5R01HL168056-03 |
| Project ID | NIH-11037960 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from obesity-related metabolic and cardiovascular issues, such as hypertension or diabetes.
✕Less likely to help
Patients who are not affected by obesity or its related complications may not benefit from this research.
What this research studies
This research focuses on understanding the role of the G-protein coupled receptor 75 (GPR75) in the complications arising from obesity, such as metabolic syndrome and cardiovascular diseases. The team aims to identify how GPR75 interacts with certain lipid mediators, specifically 20-hydroxyeicosatetraenoic acid (20-HETE), which is known to influence blood vessel function and inflammation. By studying these cellular mechanisms, the research seeks to uncover potential therapeutic targets that could improve health outcomes for individuals affected by obesity-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that mitigate the cardiovascular and metabolic complications associated with obesity.
How similar studies have gone: Previous research has shown promising results in understanding the role of GPR75 and related pathways in metabolic and cardiovascular diseases, indicating that this approach has potential for success.
Where this research is happening
-
New York Medical College
Valhalla, United States Active
Researchers
- Principal investigator: Schwartzman, Michal Laniado — New York Medical College
- Study coordinator: Schwartzman, Michal Laniado
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.