Investigating how GPNMB affects heart healing after injury
Role of GPNMB in cardiac remodeling
This study is looking at how a protein called GPNMB helps the heart heal after a heart attack, using mice to see how it affects scar tissue and heart recovery, with the hope of finding new ways to help patients recover better and avoid heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10741760 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called GPNMB in the heart's healing process following a heart attack. The study uses a genetic approach in mice to explore how GPNMB influences the formation of scar tissue and the overall remodeling of the heart. By examining how GPNMB affects heart cells and the healing process, the research aims to identify new therapeutic targets that could improve heart recovery and prevent heart failure. Patients may benefit from insights gained about GPNMB's role in heart injury and recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a heart attack and are at risk for heart failure.
Not a fit: Patients with heart conditions unrelated to myocardial infarction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart healing and reduce the risk of heart failure after a heart attack.
How similar studies have performed: Previous research has shown promise in targeting similar proteins for heart repair, suggesting that this approach could yield significant insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Deb, Arjun — University of California Los Angeles
- Study coordinator: Deb, Arjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.