Investigating how glyphosate affects metabolism through gut bacteria
The Ability of Glyphosate to Impair Metabolic Homeostasis Via the Gut Microbiome and Metabolites
This study is looking at how exposure to glyphosate, a common weed killer, might affect your metabolism and contribute to obesity and diabetes by changing the bacteria in your gut, which could help find new ways to prevent or treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10893480 on NIH RePORTER |
What this research studies
This research explores the potential effects of glyphosate, a widely used herbicide, on metabolic health, particularly focusing on its impact on obesity and diabetes. The study aims to understand how glyphosate exposure alters the gut microbiome, which plays a crucial role in regulating energy and glucose metabolism. By examining changes in bile acid metabolism and gut bacteria, the research seeks to uncover the connections between environmental chemical exposure and metabolic disorders. Patients may benefit from insights that could lead to new prevention or treatment strategies for obesity and diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be at risk for or currently experiencing obesity or diabetes.
Not a fit: Patients who are not affected by obesity or diabetes, or those who do not have any history of exposure to glyphosate, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide valuable insights into how environmental factors like glyphosate exposure contribute to obesity and diabetes, potentially leading to new prevention and treatment strategies.
How similar studies have performed: While previous studies have linked pesticide exposure to metabolic diseases, this specific investigation into glyphosate's effects on the gut microbiome and metabolic health is novel and has not been extensively tested.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Duca, Frank Anthony — University of Arizona
- Study coordinator: Duca, Frank Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.