Investigating how glutamate transport affects blood flow in Alzheimer's disease
Official title: Dysregulation of glutamate transporter-dependent neurovascular coupling in Alzheimer's disease
Funded at Drexel University · NIH-11013945 · Data updated 2026-11-12
This study is looking at how problems with a brain chemical called glutamate might affect blood flow and energy use in the brains of people with Alzheimer's, with the hope of finding new ways to help improve thinking and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $422,064 |
| NIH project number | 5R01AG081929-03 |
| Project ID | NIH-11013945 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the relationship between glutamate transport and neurovascular coupling in Alzheimer's disease. It aims to understand how disruptions in glutamate transport can lead to decreased blood flow and glucose metabolism in the brain, which may contribute to cognitive decline. The study will utilize advanced techniques to assess the functioning of astrocytes and their role in regulating blood vessel diameter in response to glutamate. By examining these mechanisms, the research seeks to uncover potential targets for therapeutic intervention.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving blood flow and metabolic function in patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding neurovascular coupling in other neurodegenerative conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Drexel University
Philadelphia, United States Active
Researchers
- Principal investigator: Jackson, Joshua Goodyear — Drexel University
- Study coordinator: Jackson, Joshua Goodyear
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.