Investigating how glutamate affects opioid and cocaine use together
Glutamergic Mechanisms in Opioid and Cocaine Co-Use
['FUNDING_OTHER'] · UNIVERSITY OF KENTUCKY · NIH-10909249
This study is looking at how using opioids and cocaine together affects the brain and hopes to find new ways to help people who are dealing with both addictions, especially by testing a treatment called n-acetylcysteine (NAC) that might help improve brain function.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KENTUCKY (nih funded) |
| Locations | 1 site (LEXINGTON, UNITED STATES) |
| Trial ID | NIH-10909249 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between opioid use disorder and cocaine use, focusing on how these substances interact in the brain. It examines the role of glutamate signaling in motivating drug use and how co-use of opioids and cocaine may alter this signaling. The study aims to identify potential new treatments that could help individuals struggling with both opioid and cocaine use disorders, particularly through the use of n-acetylcysteine (NAC), which may help restore normal brain function affected by these drugs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with opioid use disorder who also use cocaine.
Not a fit: Patients who do not have a history of opioid use disorder or cocaine use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for individuals dealing with both opioid and cocaine use disorders.
How similar studies have performed: Previous research has shown promise in using glutamatergic interventions for treating drug use disorders, suggesting that this approach may be effective.
Where this research is happening
LEXINGTON, UNITED STATES
- UNIVERSITY OF KENTUCKY — LEXINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GIPSON-REICHARDT, CASSANDRA D — UNIVERSITY OF KENTUCKY
- Study coordinator: GIPSON-REICHARDT, CASSANDRA D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.