Investigating how glucose metabolism in neurons changes in Alzheimer's due to ApoE4
Official title: Understanding how neuronal glucose metabolism changes in AD due to ApoE4
Funded at J. David Gladstone Institutes · NIH-11083767 · Data updated 2026-11-12
This study is looking at how a specific protein called ApoE4 affects how brain cells use sugar, which is important for understanding Alzheimer's Disease, and it aims to find ways to help these cells work better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 3, 2023 |
| Project end | May 2, 2026 |
| Funding year | 2025 |
| Award (this year) | $83,932 |
| NIH project number | 5F32AG082460-03 |
| Project ID | NIH-11083767 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of developing Alzheimer's Disease, particularly those who carry the ApoE4 allele.
✕Less likely to help
Patients who do not carry the ApoE4 allele or those with advanced Alzheimer's Disease may not benefit from this research.
What this research studies
This research aims to understand the relationship between apolipoprotein E4 (ApoE4) and glucose metabolism in neurons, particularly in the context of Alzheimer's Disease (AD). By using human induced pluripotent stem cell (iPSC) derived neurons and a mouse model, the study will explore how ApoE4 affects neuronal function and metabolism. The goal is to identify mechanisms that could potentially reverse metabolic dysfunction in neurons expressing ApoE4, thereby improving our understanding of AD progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for Alzheimer's Disease by targeting metabolic dysfunction in neurons.
How similar studies have gone: Previous research has shown promising results in understanding metabolic dysfunction in Alzheimer's, but this specific approach using ApoE4 and iPSC-derived neurons is relatively novel.
Where this research is happening
-
J. David Gladstone Institutes
San Francisco, United States Active
Researchers
- Principal investigator: Sei, Yoshi — J. David Gladstone Institutes
- Study coordinator: Sei, Yoshi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.