Investigating how glucocorticoids affect stress responses and metabolism in the body
Tissue Selective Glucocorticoids
This study is looking at how a hormone called cortisol affects our body and aims to create new medications that can help with inflammation and metabolism while causing fewer side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11088862 on NIH RePORTER |
What this research studies
This research focuses on understanding how the stress hormone cortisol, a type of glucocorticoid, regulates various bodily functions, including metabolism and immune responses. By developing synthetic glucocorticoids with a range of effects, researchers aim to explore how these compounds interact with specific genes to control tissue-selective activities. The study employs a technique called ligand class analysis to identify different classes of glucocorticoid ligands and their impact on gene expression. This approach could lead to more effective treatments with fewer side effects for conditions related to inflammation and metabolism.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients suffering from conditions that require glucocorticoid treatment, such as chronic inflammation or metabolic disorders.
Not a fit: Patients who do not require glucocorticoid treatment or have conditions unrelated to inflammation or metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of glucocorticoid treatments that minimize side effects while effectively managing inflammation and metabolic disorders.
How similar studies have performed: Previous research has shown promise in understanding glucocorticoid mechanisms, but this approach using ligand class analysis is relatively novel.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Nettles, Kendall W — University of Florida
- Study coordinator: Nettles, Kendall W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.