Investigating how glucocorticoids affect liver metabolism in diabetes
A Glucocorticoid Receptor-SETDB2 Co-Regulated Liver Metabolic Gene Program
This study is looking at how certain hormones called glucocorticoids affect the liver and may lead to type 2 diabetes, and it hopes to find ways to reduce their impact to help manage diabetes better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10760265 on NIH RePORTER |
What this research studies
This research explores the role of glucocorticoids, hormones that can influence metabolism, in the development of type 2 diabetes and related metabolic disorders. It focuses on how glucocorticoids interact with a specific protein, SETDB2, in the liver to regulate genes that are important for maintaining metabolic balance. By studying genetically modified mice, the research aims to understand how reducing glucocorticoid action in the liver can prevent metabolic dysfunction. This could lead to new strategies for managing diabetes and its complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes or those at risk of developing metabolic syndrome.
Not a fit: Patients with type 1 diabetes or those whose diabetes is not influenced by glucocorticoids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent or manage type 2 diabetes by targeting glucocorticoid action in the liver.
How similar studies have performed: Previous research has shown promising results in understanding the role of glucocorticoids in metabolic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Osborne, Timothy F — Johns Hopkins University
- Study coordinator: Osborne, Timothy F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.