Investigating how glucocorticoids affect glucose levels in the body
Sphingosine-1-phosphate Signaling and the Chronic Glucocorticoid Exposure Induced Glucose Homeostasis Disorder
This study is looking at how long-term stress or certain medications can affect how your body manages sugar, especially in the liver, and it hopes to find new ways to help people keep their blood sugar levels stable.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10891687 on NIH RePORTER |
What this research studies
This research explores the effects of chronic exposure to glucocorticoids, which can occur due to prolonged stress or long-term therapy, on glucose metabolism. It focuses on how these hormones influence the liver's production of glucose, particularly through a signaling molecule called sphingosine-1-phosphate. By studying the mechanisms involved, the research aims to identify potential targets for improving glucose homeostasis in affected individuals. Patients may benefit from insights that could lead to new treatment strategies for managing glucose levels.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults experiencing glucose homeostasis disorders, particularly those with a history of chronic glucocorticoid exposure.
Not a fit: Patients who do not have issues with glucose metabolism or who are not exposed to glucocorticoids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for managing glucose levels in patients with diabetes and related metabolic disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of glucocorticoids in glucose metabolism, indicating that this approach has potential for significant findings.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Wang, Jen-Chywan — University of California Berkeley
- Study coordinator: Wang, Jen-Chywan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.