Investigating how glioblastoma interacts with nearby brain regions
Official title: TARGETING SIGNALING BETWEEN GLIOBLASTOMA AND THE SUBVENTRICULAR ZONE NICHE
Funded at Mayo Clinic Jacksonville · NIH-10918651 · Data updated 2026-11-12
This study is looking at how glioblastoma tumors talk to a specific part of the brain that might affect how they grow and spread, and it invites patients to help by providing tissue samples to better understand these tumors and find new treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $449,203 |
| NIH project number | 1R01NS137907-01 |
| Project ID | NIH-10918651 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with glioblastoma, particularly those whose tumors are located near the lateral ventricles.
✕Less likely to help
Patients with glioblastoma that is not located near the lateral ventricles may not benefit from this research.
What this research studies
This research focuses on understanding the communication between glioblastoma tumors and the subventricular zone, a region in the brain that may influence tumor behavior. By using animal models and patient biopsies, the study aims to uncover how the proximity of these tumors to the lateral ventricles affects their growth and spread. The researchers will analyze the genetic and cellular interactions that occur in this environment, which could lead to new insights into treatment strategies for glioblastoma. Patients may contribute to this research through biopsies that help identify key differences in tumor characteristics.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with glioblastoma.
How similar studies have gone: Previous research has shown promising results in understanding tumor microenvironments, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Guerrero-Cazares, Hugo — Mayo Clinic Jacksonville
- Study coordinator: Guerrero-Cazares, Hugo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.