Investigating how genome structure affects gene transcription
Fine-Scale Genome Folding Relative to Transcription and Location
This study is looking at how the shape of our DNA affects how genes are turned on and off, and it's creating a new tool to help scientists better understand this process, which could lead to new insights for patients with different health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11100642 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between the three-dimensional structure of the genome and the process of gene transcription. It aims to develop advanced tools for analyzing complex genomic data, particularly through a new software called JukeBox, which will help filter and normalize data from chromatin organization assays. The project will also explore how transcription is synchronized with genome folding using serum stimulation and targeted degradation techniques. Patients may benefit from insights gained about gene regulation and its implications for various diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals with genetic disorders or cancers that involve dysregulation of gene expression.
Not a fit: Patients with conditions unrelated to genetic regulation or those not affected by chromatin structure may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding gene regulation, potentially impacting treatments for genetic disorders and cancers.
How similar studies have performed: Other research in the field of genome architecture has shown promising results, indicating that understanding the interplay between genome structure and transcription can lead to significant advancements in medical science.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Rowley, Michael Jordan — University of Nebraska Medical Center
- Study coordinator: Rowley, Michael Jordan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.