Investigating how genome structure affects gene function in individual cells
Single-cell multiomic methods for studying genome structure and function
['FUNDING_OTHER'] · UNIVERSITY OF WASHINGTON · NIH-10884769
This study is looking at how the way our genes are arranged in cells affects how they work, using a new method to see both the structure and activity of genes in individual cells, which could help us understand health and disease better for everyone.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10884769 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the three-dimensional organization of the genome within cells and how it influences gene expression. By developing a new method called CARE-seq, the project aims to simultaneously measure both the genome's structure and the activity of genes in single cells. This innovative approach will allow researchers to explore the relationship between genome architecture and gene function, particularly during developmental processes. Patients may benefit from insights gained about how genetic variations can affect health and disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders or those interested in the genetic basis of diseases.
Not a fit: Patients with conditions unrelated to genetic factors or those not interested in genetic research may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding genetic diseases and developing targeted therapies.
How similar studies have performed: Other research has shown success in using single-cell technologies to study genome function, but this specific approach of co-assessing genome structure and gene expression is novel.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUAN, ZHIJUN — UNIVERSITY OF WASHINGTON
- Study coordinator: DUAN, ZHIJUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.