Investigating how genome structure affects gene function in individual cells
Official title: Single-cell multiomic methods for studying genome structure and function
Funded at University of Washington · NIH-10884769 · Data updated 2026-11-12
This study is looking at how the way our genes are arranged in cells affects how they work, using a new method to see both the structure and activity of genes in individual cells, which could help us understand health and disease better for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 9, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $400,000 |
| NIH project number | 1R56HG013092-01 |
| Project ID | NIH-10884769 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with genetic disorders or those interested in the genetic basis of diseases.
✕Less likely to help
Patients with conditions unrelated to genetic factors or those not interested in genetic research may not receive benefit from this research.
What this research studies
This research focuses on understanding the three-dimensional organization of the genome within cells and how it influences gene expression. By developing a new method called CARE-seq, the project aims to simultaneously measure both the genome's structure and the activity of genes in single cells. This innovative approach will allow researchers to explore the relationship between genome architecture and gene function, particularly during developmental processes. Patients may benefit from insights gained about how genetic variations can affect health and disease.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding genetic diseases and developing targeted therapies.
How similar studies have gone: Other research has shown success in using single-cell technologies to study genome function, but this specific approach of co-assessing genome structure and gene expression is novel.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Duan, Zhijun — University of Washington
- Study coordinator: Duan, Zhijun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.