Investigating how genetics and environment influence telomere lengthening
Genetic and environmental factors affecting alternative lengthening of telomeres
This study is looking at how genes and the environment influence a process that helps certain cells keep their protective caps, called telomeres, from getting shorter, which is important for understanding aging and diseases like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11128535 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic and environmental factors affect a process called Alternative Lengthening of Telomeres (ALT), which helps maintain telomeres in certain cells. Telomeres are protective caps on the ends of chromosomes, and their shortening is linked to aging and various diseases, including cancer. By studying yeast cells, where ALT was first discovered, researchers aim to identify the mechanisms that allow some cells to escape aging and maintain telomere length. This could lead to insights into how environmental stressors impact telomere dynamics and contribute to age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related health issues or those with a family history of cancers associated with telomere dysfunction.
Not a fit: Patients with conditions unrelated to telomere biology or those who are not experiencing age-related pathologies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases and certain cancers by targeting telomere maintenance mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding telomere biology and its implications for aging and cancer, indicating that this approach has potential for success.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Comeron, Josep M — University of Iowa
- Study coordinator: Comeron, Josep M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.