Investigating how genetics and environment affect responses to aflatoxin exposure
Experimental Cellular Approaches to Genotype × Environment Interaction
This study is looking at how our genes and the environment work together to affect how our bodies react to harmful substances called aflatoxins found in some foods, especially for people in certain diets, and it hopes to find better ways to protect health from these risks.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Rio Grande Valley NIH-funded |
| Lab location | 1 site (Edinburg, United States) |
| Project ID | NIH-11099507 on NIH RePORTER |
What this research studies
This research explores how genetic factors and environmental influences interact to affect individual responses to aflatoxins, which are toxic compounds found in contaminated food. By utilizing cryo-preserved induced pluripotent stem cell (iPSC) lines from participants in the Mexican American Family Study, the project aims to generate liver cells to study how these cells respond to aflatoxin B1 exposure. The goal is to better understand the genetic components that contribute to health risks associated with aflatoxin exposure, particularly in populations that may be more vulnerable due to dietary habits. This research could lead to improved strategies for managing aflatoxin-related health risks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals from South Texas, particularly those with a history of exposure to aflatoxin-contaminated foods.
Not a fit: Patients who do not consume foods known to be contaminated with aflatoxins or who are not from the targeted demographic may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of health risks associated with aflatoxin exposure, potentially improving dietary safety for affected populations.
How similar studies have performed: While the investigation of genotype × environment interactions is a growing field, the specific focus on aflatoxin exposure and its genetic implications is relatively novel.
Where this research is happening
Edinburg, United States
- University of Texas Rio Grande Valley — Edinburg, United States (Active)
Researchers
- Principal investigator: Curran, Joanne E. — University of Texas Rio Grande Valley
- Study coordinator: Curran, Joanne E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.