Investigating how genetics affect treatment outcomes for alcohol use disorder
Official title: Alcohol Use Disorder: Acamprosate Pharmacometabolomics-informed Pharmacogenomics
Funded at Mayo Clinic Rochester · NIH-10978333 · Data updated 2026-11-12
This study is looking at why some people with alcohol use disorder do better on certain medications than others, and it involves giving a blood sample to help find clues that could lead to more personalized and effective treatments just for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $415,165 |
| NIH project number | 2R01AA027486-06A1 |
| Project ID | NIH-10978333 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with alcohol use disorder who are considering or currently undergoing treatment with acamprosate or naltrexone.
✕Less likely to help
Patients who do not have alcohol use disorder or are not seeking treatment for it may not benefit from this research.
What this research studies
This research focuses on understanding why some patients respond better to medications like acamprosate and naltrexone for alcohol use disorder (AUD) than others. By analyzing genetic and molecular factors, the study aims to identify biomarkers that can predict treatment success. Patients will be involved in providing blood samples, which will be analyzed to uncover these biomarkers. The ultimate goal is to develop personalized treatment plans that improve outcomes for individuals struggling with AUD.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for individuals with alcohol use disorder.
How similar studies have gone: Previous research has shown promise in using pharmacogenomics to tailor treatments for various conditions, suggesting that this approach could be beneficial for alcohol use disorder as well.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Weinshilboum, Richard M. — Mayo Clinic Rochester
- Study coordinator: Weinshilboum, Richard M.
Related research
Other NIH-funded projects on the same topics.
-
Functional Connectivity-Guided TMS for Alcohol Use Disorder
A new approach uses targeted brain stimulation to help people with alcohol use disorder stay abstinent longer by focusing treatment on specific brain circuits.
-
Alcohol Use Disorder and Suicidal Behavior: Finding Why They Occur Together
A study using Swedish population data to understand why alcohol use disorder relates to suicidal thoughts and acts, with the goal of improving risk prediction and prevention.
-
Non-hallucinogenic psilocybin derivative for alcohol use disorder
A new, safer psilocybin-like compound is being studied to help people with alcohol use disorder.
-
Identifying brain proteins linked to PTSD and alcohol use disorder
Researchers are studying brain proteins that may contribute to PTSD and alcohol use disorder in US veterans to find new ways to help people who struggle with both conditions.
-
Mu and Kappa Opioid Balance in Alcohol Use Disorder
A study using brain imaging to understand how the brain’s opioid system changes during early sobriety in adults with alcohol use disorder.
-
Telehealth support to prevent suicide in people with alcohol use disorder in Tanzania
A telehealth counseling program is being adapted to help reduce suicide risk for people with alcohol use disorder in emergency departments in Tanzania.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.