Investigating how genetics affect treatment outcomes for alcohol use disorder
Alcohol Use Disorder: Acamprosate Pharmacometabolomics-informed Pharmacogenomics
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-10978333
This study is looking at why some people with alcohol use disorder do better on certain medications than others, and it involves giving a blood sample to help find clues that could lead to more personalized and effective treatments just for you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10978333 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding why some patients respond better to medications like acamprosate and naltrexone for alcohol use disorder (AUD) than others. By analyzing genetic and molecular factors, the study aims to identify biomarkers that can predict treatment success. Patients will be involved in providing blood samples, which will be analyzed to uncover these biomarkers. The ultimate goal is to develop personalized treatment plans that improve outcomes for individuals struggling with AUD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol use disorder who are considering or currently undergoing treatment with acamprosate or naltrexone.
Not a fit: Patients who do not have alcohol use disorder or are not seeking treatment for it may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for individuals with alcohol use disorder.
How similar studies have performed: Previous research has shown promise in using pharmacogenomics to tailor treatments for various conditions, suggesting that this approach could be beneficial for alcohol use disorder as well.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEINSHILBOUM, RICHARD M. — MAYO CLINIC ROCHESTER
- Study coordinator: WEINSHILBOUM, RICHARD M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.