Investigating how genetics affect responses to stress and certain chemicals in Gulf War veterans
Genetics of epigenetic response to high circulating glucocorticoids and organophosphorus compounds
This study is looking at how genes might affect why some Gulf War veterans experience long-lasting symptoms from Gulf War Illness, using a mouse model to see how their bodies react to stress and certain chemicals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11010836 on NIH RePORTER |
What this research studies
This research explores the genetic factors that may contribute to the long-lasting symptoms experienced by Gulf War veterans, known as Gulf War Illness (GWI). By using a mouse model that simulates the exposure of troops to stress and specific chemicals, the study aims to identify how genetic variations influence the body's response to these exposures. The researchers will analyze changes in gene regulation and inflammatory responses to better understand why some individuals develop persistent symptoms while others do not.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include Gulf War veterans experiencing chronic symptoms related to GWI.
Not a fit: Patients who do not have a history of exposure to the conditions studied or those without chronic symptoms related to GWI may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted treatments for Gulf War Illness and similar conditions, improving the quality of life for affected individuals.
How similar studies have performed: Previous research has shown promising results in understanding genetic responses to environmental exposures, suggesting that this approach may yield valuable insights.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Jones, Byron C — University of Tennessee Health Sci Ctr
- Study coordinator: Jones, Byron C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.