Investigating how genetic variations in surfactant proteins affect COVID-19 severity
Roles of human surfactant collectin variants in the susceptibility of COVID-19
This study is looking at how certain genetic differences in proteins that help our lungs work might affect how seriously people get sick from COVID-19, with the hope of finding new treatments that could be personalized based on a person's genetics.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10662530 on NIH RePORTER |
What this research studies
This research focuses on understanding how different genetic variants of human surfactant proteins A and D influence the severity of COVID-19. By examining how these proteins interact with the SARS-CoV-2 virus, the study aims to uncover the mechanisms behind varying patient responses to the infection. The researchers will analyze genetic samples and conduct laboratory experiments to explore the role of these proteins in lung inflammation and injury caused by the virus. Ultimately, the goal is to identify potential therapeutic approaches tailored to specific genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with varying severities of COVID-19 who may have different genetic backgrounds.
Not a fit: Patients who have not been infected with SARS-CoV-2 or those with no genetic variations in surfactant proteins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatments for COVID-19 based on individual genetic makeup.
How similar studies have performed: Other research has shown promising results in understanding genetic factors influencing disease severity, suggesting that this approach could yield valuable insights.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Wang, Guirong — Upstate Medical University
- Study coordinator: Wang, Guirong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.