Investigating how genetic variations in APOE affect Alzheimer's disease risk
Proteomic and functional analysis of missense variants of APOE associated with Alzheimer disease risk
This study is looking at how certain changes in a gene called APOE might affect the risk of getting Alzheimer's disease, and it's for anyone interested in understanding more about the genetic factors that could help us find new ways to treat or prevent this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10898779 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genetic variations in the APOE gene influence the risk of developing Alzheimer's disease. By analyzing these variations, particularly missense variants, the study aims to uncover the molecular mechanisms that lead to changes in brain cell function and contribute to Alzheimer's. The researchers will utilize advanced techniques, including mass spectrometry and mouse astrocyte cultures, to explore how these genetic changes affect protein interactions in the brain. This could provide insights into potential therapeutic targets for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who carry specific APOE gene variants.
Not a fit: Patients without any genetic predisposition to Alzheimer's disease or those who do not carry the APOE gene variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the underlying genetic factors.
How similar studies have performed: Previous research has shown promising results in understanding the role of APOE variants in Alzheimer's disease, indicating that this approach has potential for significant findings.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Wijeratne, Hr Sagara — Indiana University Indianapolis
- Study coordinator: Wijeratne, Hr Sagara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.