Investigating how genetic variations affect the TREM2 gene linked to Alzheimer's disease risk
Official title: Regulatory variation that affects splicing of the Alzheimer's disease risk gene TREM2
Funded at University of Washington · NIH-10774052 · Data updated 2026-11-12
This study is looking at how certain genetic changes affect a gene linked to Alzheimer's disease, with the hope of finding new ways to detect the disease early and develop better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 30, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $759,146 |
| NIH project number | 1R01AG084684-01 |
| Project ID | NIH-10774052 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who carry known risk alleles such as APOE e4 or TREM2 variants.
✕Less likely to help
Patients without a genetic predisposition to Alzheimer's disease or those who do not exhibit any symptoms of cognitive decline may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic variations influence the splicing of the TREM2 gene, which is associated with Alzheimer's disease (AD). By examining noncoding variants that regulate gene expression, the study aims to uncover new insights into the genetic factors contributing to AD risk. Patients may benefit from this research as it could lead to the identification of new biomarkers for early detection and potential therapeutic targets. The approach involves analyzing genetic samples and their effects on gene splicing in relation to AD pathology.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of Alzheimer's disease, potentially paving the way for new treatments.
How similar studies have gone: Previous research has shown promise in understanding the role of genetic variations in Alzheimer's disease, making this approach a continuation of established scientific inquiry.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Korvatska, Olena — University of Washington
- Study coordinator: Korvatska, Olena
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.