Investigating how genetic variations affect susceptibility to Staphylococcus aureus infections
Official title: ADAM10 polymorphism in susceptibility to S. aureus disease
Funded at Washington University · NIH-10796998 · Data updated 2026-11-12
This study is looking at how certain changes in a gene called ADAM10 might affect whether kids and adults get infections from a common germ called Staphylococcus aureus, with the goal of finding ways to better predict and treat these infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $194,375 |
| NIH project number | 5R21AI176063-02 |
| Project ID | NIH-10796998 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals of all ages, particularly those with a history of recurrent Staphylococcus aureus infections.
✕Less likely to help
Patients who do not have a history of Staphylococcus aureus infections or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic variations in the ADAM10 gene may influence an individual's risk of developing infections caused by Staphylococcus aureus, a common and potentially dangerous bacterium. By studying both children and adults, the research aims to identify factors that affect immune response and susceptibility to these infections. The approach includes analyzing genetic samples and clinical data to develop tools that can help predict individual risk, ultimately contributing to personalized treatment strategies. The findings could lead to improved vaccine designs and better management of S. aureus infections.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention strategies and treatments for Staphylococcus aureus infections, reducing morbidity and mortality rates.
How similar studies have gone: Previous research has shown promise in understanding genetic factors related to infectious diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Bubeck Wardenburg, Juliane — Washington University
- Study coordinator: Bubeck Wardenburg, Juliane
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.