Investigating how genetic variations affect brain cell communication in autism.
Simultaneous profiling of neuronal synapse activities, proteins, and messenger RNAs at the single-cell level
This study is looking at how certain genes affect brain connections in people with autism, using special imaging techniques to see how these connections work, which could help find new ways to support individuals with autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11049919 on NIH RePORTER |
What this research studies
This research focuses on autism spectrum disorder (ASD), a condition that impacts cognitive and communication abilities. By using advanced imaging techniques, the study aims to observe the activities of neuronal synapses at a single-cell level, examining how specific genetic variations influence the development and function of these synapses. The approach combines live-cell imaging with molecular characterization of proteins and messenger RNAs, allowing for a detailed understanding of synaptic behavior in ASD. This could lead to the identification of new therapeutic targets for improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder.
Not a fit: Patients without a diagnosis of autism spectrum disorder or related neurodevelopmental conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive and communication skills in individuals with autism.
How similar studies have performed: Previous research has successfully utilized similar imaging techniques to study synaptic proteins, indicating potential for success in this novel approach.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Bathe, Mark — Massachusetts Institute of Technology
- Study coordinator: Bathe, Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.