Investigating how genetic variants in Alzheimer's disease affect the blood-brain barrier.
Cell and Molecular Consequences of Alzheimer's Disease Genetic Variants on BBB Integrity and Function
This study is looking at how certain genetic changes linked to Alzheimer's disease affect the protective barrier in the brain, using special lab models that act like human brains, to help us better understand the disease and its effects on people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10611806 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic mutations associated with Alzheimer's disease influence the integrity and function of the blood-brain barrier (BBB). Using advanced 3D organ-on-chip models that mimic human physiology, researchers will study the effects of various genetic risk factors on BBB function. By utilizing induced pluripotent stem cells (iPSCs) from individuals with different genetic backgrounds, the study aims to uncover the molecular pathways affected by these genetic variants. This approach seeks to bridge the gap between animal models and human biology to provide insights into Alzheimer's disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with early- or late-onset Alzheimer's disease and those carrying specific genetic risk factors.
Not a fit: Patients without any genetic predisposition to Alzheimer's disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that protect or restore blood-brain barrier function in Alzheimer's patients.
How similar studies have performed: Previous studies using organ-on-chip technology have shown promise in understanding disease mechanisms, suggesting potential success for this novel approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Young-Pearse, Tracy L — Brigham and Women's Hospital
- Study coordinator: Young-Pearse, Tracy L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.