Investigating how genetic signals shape tissue development in embryos
Official title: Using genetics and optogenetics to dissect how Rho signaling is coordinated at distinct subcellular domains to drive epithelial tissue morphogenesis
Funded at Columbia Univ New York Morningside · NIH-11165126 · Data updated 2026-11-12
This study is looking at how tiny forces created by cells help shape tissues in developing embryos, using fruit flies to learn more about how genes and proteins work together, which could help us understand some birth defects better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 1F31HD118793-01 |
| Project ID | NIH-11165126 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital anomalies or developmental disorders related to tissue formation.
✕Less likely to help
Patients with conditions unrelated to tissue morphogenesis or genetic signaling may not benefit from this research.
What this research studies
This research focuses on understanding the mechanical forces generated by cellular structures during the development of epithelial tissues in embryos. By using the fruit fly, Drosophila melanogaster, as a model organism, the study aims to explore how specific genetic and protein interactions influence the shape and arrangement of cells. The researchers will analyze the dynamics of actomyosin, a protein complex that plays a crucial role in cell movement and shape, at various cellular locations during key developmental processes. This approach will help uncover the underlying mechanisms that guide tissue formation and may provide insights into congenital anomalies.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of congenital anomalies and potential therapeutic strategies for tissue development disorders.
How similar studies have gone: Previous research has shown success in using genetic models to understand tissue development, making this approach promising and relevant.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Countryman, Andrew Dylan — Columbia Univ New York Morningside
- Study coordinator: Countryman, Andrew Dylan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.