Investigating how genetic risk for Alzheimer's affects brain development in children
Measuring neurodevelopmental effects of polygenic risk for Alzheimer's disease via longitudinal study of brain and cognitive variables in periadolescent children
['FUNDING_R01'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-10613526
This study is looking at how certain genes linked to Alzheimer's might affect the brain and thinking skills of kids in their early teens, to see if understanding these changes can help find ways to support those who may be at risk for Alzheimer's later on.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-10613526 on ClinicalTrials.gov |
What this research studies
This research examines the impact of genetic factors associated with Alzheimer's disease on the brain and cognitive development of periadolescent children. By tracking brain and cognitive changes over time, the study aims to understand how these genetic risks may influence vulnerability to Alzheimer's later in life. Participants will undergo assessments that measure various cognitive abilities and brain structures, particularly focusing on areas like the hippocampus that are crucial for memory. The findings could help identify early interventions for those at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are periadolescent children with a family history of Alzheimer's disease or those identified as having a genetic predisposition to the condition.
Not a fit: Patients who are already diagnosed with Alzheimer's disease or those outside the periadolescent age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early identification of children at risk for Alzheimer's, allowing for preventive strategies to be implemented.
How similar studies have performed: Other research has shown promising results in understanding the genetic influences on neurodevelopment and Alzheimer's risk, suggesting that this approach could yield valuable insights.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WARREN, DAVID E — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: WARREN, DAVID E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.