Investigating how genetic risk factors affect protein recycling in neurodegenerative diseases.
Official title: Endolysosomal Proteome Landscapes Through the Lens of Neurodegenerative Risk Alleles
Funded at Harvard Medical School · NIH-11048181 · Data updated 2026-11-12
This study is looking at how certain genes linked to Alzheimer's and similar conditions affect how our cells break down and recycle proteins, with the hope that understanding these processes can help develop better treatments or ways to prevent these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 19, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $614,617 |
| NIH project number | 2R01NS110395-06A1 |
| Project ID | NIH-11048181 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic risk factors for Alzheimer's Disease or related dementias.
✕Less likely to help
Patients without genetic risk factors for Alzheimer's Disease or those with unrelated neurodegenerative conditions may not benefit from this research.
What this research studies
This research focuses on understanding the endolysosomal system, which is crucial for degrading and recycling proteins in cells. It aims to explore how genetic risk factors associated with Alzheimer's Disease and related dementias influence the trafficking and degradation of proteins within this system. By examining the role of specific proteins and their interactions, the research seeks to uncover the mechanisms that lead to neurodegenerative conditions. Patients may benefit from insights that could inform future treatments or preventive strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for Alzheimer's Disease and related dementias by targeting the underlying mechanisms of protein dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding the role of endolysosomal dysfunction in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Harper, Jeffrey W — Harvard Medical School
- Study coordinator: Harper, Jeffrey W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.