Investigating how genetic risk and inflammation affect brain health in older adults.
Brain Vulnerability in Delirium and Alzheimer’s Disease and Related Dementias: Intersection of Polygenic Risk and Inflammation
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-10987037
This study is looking at how certain genes linked to Alzheimer's and other dementias work with inflammation to affect brain health in older adults, especially after things like surgery or infections, to help identify those who might be at greater risk for memory problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10987037 on ClinicalTrials.gov |
What this research studies
This research aims to understand how genetic factors related to Alzheimer's Disease and related dementias interact with inflammation to influence brain health in older adults. By examining the genetic predisposition of individuals, the study seeks to identify those who may be at higher risk for developing conditions like delirium and cognitive decline, especially after experiencing inflammatory events such as surgery or infections. The approach involves analyzing multiple genetic markers rather than focusing on single genes, allowing for a more comprehensive understanding of the risks involved. This research could lead to better identification of vulnerable individuals and inform preventive strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and above, who may have a genetic predisposition to Alzheimer's Disease or related dementias.
Not a fit: Patients under the age of 65 or those without a genetic risk for Alzheimer's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cognitive decline and delirium in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the links between genetic risk factors and cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VASUNILASHORN, SARINNAPHA — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: VASUNILASHORN, SARINNAPHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.