Investigating how genetic mutations and folic acid affect meningomyelocele in mice
Project III - Modeling meningomyelocele alleles and response to folic acid diet in mouse
This study is looking at how certain genetic changes and a diet high in folic acid might affect the risk of meningomyelocele, a type of birth defect, using mice to help us understand how these factors work together to support healthy development.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11017629 on NIH RePORTER |
What this research studies
This research explores the role of genetic mutations in the risk of meningomyelocele, a type of neural tube defect, and how a diet rich in folic acid may influence this risk. Using mice as a model, the study examines how folic acid affects gene expression and chromatin accessibility, which are crucial for proper neural tube development. The research aims to identify specific genetic factors and their interactions with environmental influences, such as diet, that contribute to the occurrence of these defects. By understanding these mechanisms, the study hopes to provide insights that could lead to preventive strategies for humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of meningomyelocele or other neural tube defects.
Not a fit: Patients without a genetic predisposition to neural tube defects or those not planning to conceive may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for meningomyelocele and other neural tube defects in humans.
How similar studies have performed: Previous research has shown success in using mouse models to study genetic factors and environmental influences on neural tube defects, indicating that this approach is well-established.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Niswander, Lee a. — University of California, San Diego
- Study coordinator: Niswander, Lee a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.