Investigating how genetic mutations affect brain development related to psychiatric disorders
Official title: Neurodevelopmental defects of the thalamocortical pathway as a convergent feature of psychiatric disorders
Funded at University of California, San Francisco · NIH-11010809 · Data updated 2026-11-12
This study is looking at how certain genes affect the way brain connections develop, especially those that help us process senses and think, to better understand conditions like autism and ADHD, which could lead to new treatment options for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $642,771 |
| NIH project number | 5R01MH128364-03 |
| Project ID | NIH-11010809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with conditions such as autism spectrum disorder, ADHD, or those with genetic mutations associated with neurodevelopmental disorders.
✕Less likely to help
Patients without neurodevelopmental psychiatric disorders or those not carrying relevant genetic mutations may not benefit from this research.
What this research studies
This research explores the genetic factors that influence the development of neural circuits in the brain, particularly focusing on the thalamocortical pathway, which is crucial for sensory and cognitive functions. By studying how mutations in specific genes disrupt the early stages of brain cell development, the research aims to uncover the underlying mechanisms that lead to neurodevelopmental psychiatric disorders. Patients may benefit from insights gained through this research, as it could inform new treatment strategies and interventions for conditions like autism and ADHD.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with neurodevelopmental psychiatric disorders.
How similar studies have gone: Previous research has shown promise in understanding genetic influences on brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Nowakowski, Tomasz — University of California, San Francisco
- Study coordinator: Nowakowski, Tomasz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.