Investigating how genetic mixing between species affects evolution and health.
The population genomics of hybridization: from genetic incompatibilities to genome evolution
This study is looking at how mixing genes from different species, like swordtail fish, affects their health and development, helping us understand both the good and bad changes that can happen, including issues like skin cancer and problems during early growth.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11175162 on NIH RePORTER |
What this research studies
This research explores the effects of hybridization, or genetic exchange between different species, on their genomes and biological processes. By utilizing advanced genome sequencing techniques, the project aims to understand the genetic interactions that occur when species hybridize, which can lead to both beneficial adaptations and detrimental health issues, such as disease susceptibility. The research employs a combination of computational methods and biological models, particularly focusing on swordtail fish, to map genetic interactions and their consequences. This work seeks to uncover the molecular mechanisms behind issues like melanoma and embryonic lethality in hybrids.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases that may be influenced by hybridization and genetic interactions.
Not a fit: Patients who do not have genetic disorders or are not affected by hybridization-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic diseases and improve strategies for managing health risks associated with hybridization.
How similar studies have performed: Other research has shown promising results in understanding hybridization's role in evolution and health, indicating that this approach has potential for significant findings.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Schumer, Molly — Stanford University
- Study coordinator: Schumer, Molly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.