Investigating how genetic mixing between species affects evolution and disease.
The population genomics of hybridization: from genetic incompatibilities to genome evolution
This study looks at how different species, like swordtails, mix their genes and how that can affect their health and development, helping us understand why some hybrids might be more prone to diseases or other problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10841347 on NIH RePORTER |
What this research studies
This research explores the phenomenon of hybridization, where genetic material is exchanged between different species, and its implications for evolution and health. By utilizing advanced genome sequencing techniques, the study aims to understand the genetic interactions that can lead to issues such as disease susceptibility and developmental problems in hybrids. The research employs a model system using swordtails to identify specific genetic incompatibilities and their effects on health outcomes. Ultimately, the goal is to create a comprehensive map of these genetic interactions and their consequences for various biological processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of genetic disorders or those affected by conditions linked to hybridization, such as certain types of melanoma.
Not a fit: Patients who do not have a genetic predisposition to diseases influenced by hybridization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic diseases and better strategies for managing health risks associated with hybridization.
How similar studies have performed: Previous research has shown promising results in understanding hybridization's role in evolution and disease, indicating that this approach has potential for significant insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Schumer, Molly — Stanford University
- Study coordinator: Schumer, Molly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.