Investigating how genetic factors linked to Alzheimer's disease affect sleep patterns.
Official title: Do Genetic Risk Variants for Alzheimer's Disease have a Pleotropic Effect on Sleep?
Funded at University of Pennsylvania · NIH-11037502 · Data updated 2026-11-12
This study is looking at how certain genes linked to Alzheimer's disease might affect how well people sleep, helping us understand if these genetic factors can give us clues about early signs of Alzheimer's and sleep problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $446,875 |
| NIH project number | 1R21AG091081-01 |
| Project ID | NIH-11037502 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those experiencing sleep disturbances.
✕Less likely to help
Patients without any genetic predisposition to Alzheimer's disease or significant sleep issues may not benefit from this research.
What this research studies
This research explores the connection between genetic risk factors for Alzheimer's disease and their potential impact on sleep disturbances. It aims to determine whether genetic variants associated with Alzheimer's also influence sleep duration and quality. By utilizing advanced genome-wide association studies and chromatin interaction mapping, the researchers will analyze how these genetic factors interact with environmental influences to affect sleep. This could provide insights into the early signs of Alzheimer's disease and its relationship with sleep.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of sleep disturbances as early indicators of Alzheimer's disease, potentially guiding early interventions.
How similar studies have gone: Previous research has shown promising results in understanding the genetic links between sleep and Alzheimer's, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Pack, Allan I — University of Pennsylvania
- Study coordinator: Pack, Allan I
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.