Investigating how genetic factors link a common blood condition to heart disease
Official title: Using genomic modifiers to mechanistically link clonal hematopoiesis of indeterminate potential penetrance to coronary artery disease
Funded at Broad Institute, INC. · NIH-10827517 · Data updated 2026-11-12
This study is looking at how a certain genetic change, called CHIP, might be linked to heart disease in older adults, with the goal of finding better ways to prevent heart problems for those at risk.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $166,860 |
| NIH project number | 5K99HL165024-02 |
| Project ID | NIH-10827517 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those over 70 years old, who have been diagnosed with clonal hematopoiesis of indeterminate potential.
✕Less likely to help
Patients without clonal hematopoiesis or those under 70 years old may not benefit from this research.
What this research studies
This research explores the connection between clonal hematopoiesis of indeterminate potential (CHIP) and coronary artery disease (CAD), particularly in older adults. By analyzing human genomic data and using advanced multi-omics techniques, the study aims to uncover the mechanisms that increase the risk of CAD in individuals with CHIP. The research focuses on understanding specific genetic markers and their roles in the development of heart disease, which could lead to improved prevention strategies for at-risk patients.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and management strategies for heart disease in patients with CHIP.
How similar studies have gone: Previous research has shown promising results in linking genetic factors to cardiovascular disease, indicating that this approach has potential for success.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Nakao, Tetsushi — Broad Institute, INC.
- Study coordinator: Nakao, Tetsushi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.