Investigating how genetic factors influence disease through regulatory mechanisms.
Using the continuum of genetic causality to investigate trans regulatory mechanisms.
['FUNDING_CAREER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10948548
This study is looking at how certain genetic differences can change the way our genes work and affect the risk of diseases like diabetes, using cutting-edge tools to better understand these connections.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10948548 on ClinicalTrials.gov |
What this research studies
This research explores how genetic variations in noncoding regions of the genome affect disease risk by altering gene regulation. It focuses on understanding trans regulatory mechanisms, which are influenced by transcription factors that can impact multiple genes. The study employs advanced techniques such as CRISPR screening and genomic profiling to construct regulatory networks and analyze their roles in complex diseases like diabetes. By integrating genetic data, the research aims to uncover the connections between monogenic and complex diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of diabetes or other complex diseases linked to genetic factors.
Not a fit: Patients with purely environmental causes of their conditions or those without any genetic predisposition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic underpinnings of complex diseases, potentially informing targeted therapies.
How similar studies have performed: Previous research has shown promise in understanding gene regulation through similar genomic approaches, indicating potential for success in this area.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOVAR, ADELAIDE E — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: TOVAR, ADELAIDE E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus