Investigating how genetic factors influence disease through regulatory mechanisms.
Official title: Using the continuum of genetic causality to investigate trans regulatory mechanisms.
Funded at University of Michigan at Ann Arbor · NIH-10948548 · Data updated 2026-11-12
This study is looking at how certain genetic differences can change the way our genes work and affect the risk of diseases like diabetes, using cutting-edge tools to better understand these connections.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 29, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $119,611 |
| NIH project number | 1K99HG013676-01 |
| Project ID | NIH-10948548 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of diabetes or other complex diseases linked to genetic factors.
✕Less likely to help
Patients with purely environmental causes of their conditions or those without any genetic predisposition may not benefit from this research.
What this research studies
This research explores how genetic variations in noncoding regions of the genome affect disease risk by altering gene regulation. It focuses on understanding trans regulatory mechanisms, which are influenced by transcription factors that can impact multiple genes. The study employs advanced techniques such as CRISPR screening and genomic profiling to construct regulatory networks and analyze their roles in complex diseases like diabetes. By integrating genetic data, the research aims to uncover the connections between monogenic and complex diseases.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic underpinnings of complex diseases, potentially informing targeted therapies.
How similar studies have gone: Previous research has shown promise in understanding gene regulation through similar genomic approaches, indicating potential for success in this area.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Tovar, Adelaide E — University of Michigan at Ann Arbor
- Study coordinator: Tovar, Adelaide E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.