Investigating how genetic factors influence Alzheimer's disease risk
Modeling the Genetic Interaction Between Klotho and APOE Alleles in Alzheimer's Disease
This study is looking at how certain genes might work together to affect the risk of getting late-onset Alzheimer's disease, using mice to help us understand why some people with a high genetic risk don’t actually get the disease, which could help us find new ways to prevent it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-10524407 on NIH RePORTER |
What this research studies
This research explores the interaction between specific genetic variants, particularly the Klotho and APOE alleles, to understand their combined effect on the risk of developing late-onset Alzheimer's disease. By using mouse models that mimic human genetic variations, the study aims to identify how these genetic factors can alter physiological processes and potentially lead to protective strategies against Alzheimer's. The research focuses on understanding why some individuals with a high genetic risk do not develop the disease, which could inform future therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who carry the APOE4 allele and may also have variations in the Klotho gene.
Not a fit: Patients who do not carry the APOE4 allele or have no family history of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying the onset of Alzheimer's disease in genetically at-risk individuals.
How similar studies have performed: Previous research has shown that genetic interactions can influence Alzheimer's disease risk, suggesting that this approach has potential for success.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Carter, Gregory W — Jackson Laboratory
- Study coordinator: Carter, Gregory W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.