Investigating how genetic factors affect obesity through brain cells
Human hypothalamic neuronal epigenomics and risk for obesity
['FUNDING_R01'] · TEXAS A&M UNIVERSITY-SAN ANTONIO · NIH-10836243
This study is looking at how our genes might affect obesity by examining brain cells that help control our energy balance, and it's designed for anyone interested in understanding the biological factors behind weight gain.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M UNIVERSITY-SAN ANTONIO (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-10836243 on ClinicalTrials.gov |
What this research studies
This research aims to understand how genetic variations influence obesity by focusing on the hypothalamus, the brain region that regulates energy balance. Researchers will use human induced pluripotent stem cells to create neuronal cultures that mimic hypothalamic neurons, allowing them to study the molecular mechanisms involved in obesity. By mapping the regulatory landscape of these neurons, the research seeks to identify specific genetic factors that contribute to obesity risk. This approach overcomes challenges related to accessing human brain tissue for study.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of obesity or those who are genetically predisposed to weight gain.
Not a fit: Patients who are not genetically predisposed to obesity or those with obesity due to environmental factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions and therapies for obesity based on genetic insights.
How similar studies have performed: While the specific approach of using iPSC-derived neuronal cultures is innovative, similar research has shown promise in understanding genetic influences on other conditions.
Where this research is happening
SAN ANTONIO, UNITED STATES
- TEXAS A&M UNIVERSITY-SAN ANTONIO — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEHMAN, DONNA M — TEXAS A&M UNIVERSITY-SAN ANTONIO
- Study coordinator: LEHMAN, DONNA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.