Investigating how genetic factors affect immune responses in Alzheimer's disease
Alzheimer's Disease Genetic Risk and Microglial Innate Immune Memory
This study is looking at how certain genes affect the brain's immune cells in people with Alzheimer's disease, hoping to find new ways to help improve treatment by understanding how these cells respond to the disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10906795 on NIH RePORTER |
What this research studies
This research explores the role of microglia, the brain's immune cells, in Alzheimer's disease (AD) and how genetic variations influence their function. It focuses on innate immune memory, a process where the initial immune response shapes future reactions, potentially affecting the progression of AD. By studying specific genetic risk factors, particularly the CD33 variant, the research aims to understand how these factors alter microglial behavior and contribute to the disease's pathology. Patients may benefit from insights that could lead to new therapeutic strategies targeting microglial dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a genetic predisposition to Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients without any genetic risk factors for Alzheimer's disease or those with advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance microglial function and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding microglial function and its implications in Alzheimer's disease, indicating that this approach has potential for significant findings.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Chatila, Zena — Columbia University Health Sciences
- Study coordinator: Chatila, Zena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.