Investigating how genetic factors affect gastric cancer outcomes in Hispanic/Latino patients
Determining the role of germline CDH1 variants in gastric cancer outcome disparities in Hispanic/Latino patients
This study is looking into why Hispanic and Latino patients often get more aggressive gastric cancer at younger ages, by checking for specific genetic changes that might be involved, with the hope of finding better ways to diagnose and treat this condition.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10900741 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors that contribute to gastric cancer disparities among Hispanic/Latino patients. It aims to identify the prevalence of germline CDH1 variants, which are linked to hereditary diffuse gastric cancer syndrome, in this population. By analyzing genetic data and patient characteristics, the study seeks to uncover why Hispanic/Latino patients experience more aggressive forms of gastric cancer at younger ages. The findings could lead to improved diagnostic tools and targeted interventions for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are Hispanic/Latino individuals diagnosed with gastric cancer, particularly those with diffuse gastric cancer.
Not a fit: Patients who do not identify as Hispanic/Latino or those without a diagnosis of gastric cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of gastric cancer in Hispanic/Latino patients, potentially improving their outcomes.
How similar studies have performed: Previous research has shown that genetic factors play a significant role in cancer disparities, suggesting that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Wang, Sam C. — Ut Southwestern Medical Center
- Study coordinator: Wang, Sam C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.