Investigating how genetic factors affect brain structure and cognitive aging in mice with Alzheimer's disease
Imaging Genetics of Brain Structure and Cognitive Aging in Murine Models of Alzheimer's Disease
This study is looking at how certain genes linked to familial Alzheimer's disease affect the brain and thinking skills in aging mice, which could help us understand more about Alzheimer's and how our brains change as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11011361 on NIH RePORTER |
What this research studies
This research explores the relationship between genetic variants associated with familial Alzheimer's disease and changes in brain structure and function in aging mice. By using advanced imaging techniques like MRI and behavioral assessments, the study aims to uncover the mechanisms behind age-related cognitive decline and Alzheimer's pathology. The researchers will analyze data from various mouse models to identify how specific genes influence cognitive abilities and brain health over time. This comprehensive approach may help in understanding the complexities of Alzheimer's disease and cognitive aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease or those experiencing early signs of cognitive decline.
Not a fit: Patients with no genetic predisposition to Alzheimer's disease or those who are not experiencing cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic factors that contribute to cognitive decline and Alzheimer's disease, potentially guiding future treatments.
How similar studies have performed: Previous research has shown promising results in understanding genetic influences on cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Williams, Robert W. — University of Tennessee Health Sci Ctr
- Study coordinator: Williams, Robert W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.