Investigating how genetic differences in a platelet receptor affect blood clotting and stroke risk.
Official title: HUMAN PLATELET PAR4: NOVEL ACTIVATION, INTERINDIVIDUAL VARIATION, AND NEUTROPHIL INTERACTIONS IN VIVO AND IN VITRO
Funded at Washington University · NIH-11194655 · Data updated 2026-11-12
This study is looking at how certain genetic differences in a protein called PAR4 might affect how our blood platelets work and the risk of having a stroke, so that people can learn more about their own genetic risks for stroke and bleeding.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | October 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $509,165 |
| NIH project number | 7R01HL160808-04 |
| Project ID | NIH-11194655 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of ischemic stroke or those who have experienced unexplained bleeding or clotting issues.
✕Less likely to help
Patients who do not have any genetic variations related to PAR4 or those with conditions unrelated to platelet function may not benefit from this research.
What this research studies
This research focuses on understanding how variations in the protease activated receptor-4 (PAR4) influence platelet function and the risk of ischemic stroke. By studying genetic differences, particularly the Ala120Thr variant, the research aims to uncover how these variations affect platelet aggregation and interactions with other receptors. The team will utilize both in vitro and in vivo models to explore these mechanisms, providing insights into how these genetic factors contribute to blood clotting and potential stroke outcomes. Patients may benefit from a better understanding of their genetic risk factors for stroke and bleeding.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies for patients at risk of ischemic stroke based on their genetic profile.
How similar studies have gone: Previous research has successfully identified genetic factors influencing platelet function, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Campbell, Robert a — Washington University
- Study coordinator: Campbell, Robert a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.