Investigating how genetic differences affect lupus in African American patients
Disease and Race Specific Single-cell Epigenetic Mechanisms in Human SLE
This study is looking at how lupus affects people differently based on their background, especially between European American and African American patients, to find out how certain genetic factors influence the disease and improve treatment for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11078854 on NIH RePORTER |
What this research studies
This research focuses on systemic lupus erythematosus (SLE), an autoimmune disease that affects individuals differently based on their genetic background, particularly between European American and African American patients. The team will use advanced techniques to analyze how epigenetic factors influence the disease's progression and severity in these populations. By examining specific cell types from blood samples, they aim to uncover the underlying mechanisms that contribute to the disparities in diagnosis and treatment outcomes. This work could lead to more personalized approaches to managing lupus in diverse patient groups.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American individuals diagnosed with systemic lupus erythematosus.
Not a fit: Patients who do not have lupus or those from other racial backgrounds may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for African American patients with lupus.
How similar studies have performed: Other research has shown success in understanding genetic and epigenetic factors in autoimmune diseases, but this specific focus on race-specific mechanisms in lupus is relatively novel.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Gaffney, Patrick M — Oklahoma Medical Research Foundation
- Study coordinator: Gaffney, Patrick M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.