Investigating how genetic differences affect cholesterol levels in the body
High-throughput investigation of human genetic variants affecting cholesterol uptake and efflux
This study is looking at how our genes affect cholesterol levels in the body, which can help us understand heart disease better, and it aims to find new ways to create personalized treatments for patients based on their unique genetic makeup.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10870195 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic variations influence cholesterol uptake and efflux, which are critical factors in the risk of coronary artery disease. By utilizing advanced techniques such as CRISPR screening and gene network analysis, the study aims to identify new genes that affect LDL cholesterol levels. Patients may benefit from insights gained through this research, as it could lead to the development of targeted therapies for heart disease based on individual genetic profiles. The research will analyze data from large biobanks to correlate genetic variants with cholesterol metabolism.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of high cholesterol or coronary artery disease, as well as those with unexplained variations in cholesterol levels.
Not a fit: Patients who do not have any genetic predisposition to cholesterol metabolism issues or those without a history of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatments for managing cholesterol levels and reducing the risk of heart disease.
How similar studies have performed: Previous research using similar CRISPR-based approaches has shown promise in identifying genetic factors influencing various health conditions, suggesting potential success for this study.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Sherwood, Richard I — Brigham and Women's Hospital
- Study coordinator: Sherwood, Richard I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.